Looking for a new potential treatment option to help control your Graves’ disease?

Living with a diagnosis of Graves’ disease (GD) is often characterized by the need to restore a sense of balance. Despite taking antithyroid drugs, you might still feel overwhelmed by your symptoms. Fatigue can make daily tasks feel daunting — especially when dealing with a racing heart, weight loss, and a range of other potential symptoms knocking you off course. By participating in the FORWARD clinical trial, you are contributing to research that is exploring whether an investigational treatment can address the underlying cause of Graves’ disease.

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How It Works

Starting the process is simple and only takes a few minutes

Complete The Survey

Answer some brief questions and we’ll let you know whether you may be eligible to participate in the study.

Schedule An Appointment

If you qualify, the next step is speaking with a team member. Just find 10 – 15 free minutes in your day and we’ll get you connected.

Speak To A Team Member

Our dedicated specialists understand your situation and will listen, answer your questions, and address your concerns. We’re here to help.

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Understanding Graves’ Disease (GD)

What Exactly Is Graves’ Disease?

Graves’ disease is caused by the body’s disease-fighting immune system not working correctly.^1. The same immune system that makes antibodies to target viruses, bacteria, or other foreign substances can make antibodies that target cells in the thyroid. When this happens, it can cause a disruption in thyroid hormone production. The antibody linked with Graves’ disease causes the thyroid to make more thyroid hormone than the body needs. That condition is called hyperthyroidism, and Graves’ disease is the most common form of it.

How Is It Treated?

Producing too much thyroid hormone, as is the case with Graves’ disease/hyperthyroidism, can affect many areas of the body, including your heart, eyes, skin, bones, muscles and liver. An excess of thyroid hormone can cause heart palpitations, tremors, anxiety, and your bones to weaken (osteoporosis), and can lead to more serious heart conditions. Treatment for GD aims to stop the thyroid from making hormones, as in the case of radioactive iodine therapy and medications designed to block thyroid hormone from being made, or it aims to block the effect of those hormones on the body, as in the case of beta blockers.

There is also the option for surgery to remove all or part of the thyroid gland, called a thyroidectomy.2. However, as you may be aware, while effective, invasive surgical or radiation therapies can carry risks and leave people with the lifelong effects of losing their thyroid gland. This requires chronic medication for hypothyroidism to manage symptoms such as fatigue, skin problems, weight gain and depression. For these reasons, many people are looking to expand their care options, and clinical trials can offer that avenue.

What We Hope To Do

Study sponsor Immunovant understands the need for new treatment options. The investigational treatment being examined in the FORWARD program clinical studies, IMVT-1402, is thought to work in a different way than currently available antithyroid drugs. It is designed to target the underlying cause of Graves’ disease. Clinical trials are the only way to investigate potential new treatments. By participating, patients may potentially benefit others living with GD. It is people like you who are helping scientists advance research and possibly improve treatments for Graves’ disease.

Women are five times more likely to develop Graves’ disease than men³.

1. Source: https://my.clevelandclinic.org/health/diseases/15244-graves-disease

2. Source: https://www.mayoclinic.org/diseases-conditions/graves-disease/diagnosis-treatment/drc-20356245

3. Source: https://www.niddk.nih.gov/health-information/endocrine-diseases/graves-disease#:~:text=Graves’%20disease%20affects%20nearly%201%20in%20100%20Americans

Who Can Participate?

This trial is enrolling people aged 18 to 75 who:

Have been diagnosed with Graves’ disease
Have been taking antithyroid drugs (like tapazole) for at least 3 months by the time they begin the study
Have not undergone Radioactive Iodine Therapy or complete thyroidectomy

Why Take Part?

Clinical trials are the only way to investigate potential new treatments. By participating, you may potentially benefit other people with Graves’ disease in future generations. You will also receive attentive care from a team skilled in the treatment of Graves’ disease throughout the trial.

There are other requirements which the study team will discuss with you. Learn more about our participation criteria to see if you may be a good fit for this trial.

See If You Qualify

Frequently Asked Questions

What are the symptoms of Graves’ disease?

Signs may include:^4.

Rapid heartbeat
Having a slight tremor of the hands or fingers.
Feeling nervous and irritable
Enlarged thyroid gland
Bulging eyes, called thyroid eye disease or Graves’ ophthalmopathy
Sensitivity or intolerance to heat with increased sweating
Weight loss, despite increased appetite
Diarrhea
Hair loss/change in texture
Menstrual changes
Difficulty sleeping
Muscle weakness
Thick, discolored skin often on the shins or tops of the feet, called Graves’ dermopathy

4. Source: https://www.mayoclinic.org/diseases-conditions/graves-disease/symptoms-causes/syc-20356240

Who may be a good candidate to apply for this study?

This trial is enrolling people aged 18 to 75 who:

Have been diagnosed with Graves’ disease
Have been taking antithyroid drugs for at least 3 months by the time they begin the study
Have not undergone Radioactive Iodine Therapy or complete thyroidectomy

There are other requirements which the study team will discuss with you. Read on to learn more about our participation criteria to see if you may be a good fit for this trial.

What will happen during the study?

The FORWARD trials are evaluating whether an investigational treatment, called IMVT-1402, can address the underlying cause of Graves’ disease, and potentially normalize thyroid hormone levels. “Investigational” means that the drug has not been approved for use in patients, except in a clinical study. At the beginning of the trial, you will be assigned by chance to receive either the investigational treatment or a placebo (which looks the same but does not contain any active ingredient), in addition to your standard antithyroid drugs. You will have a 66% chance of receiving the investigational treatment. The investigational treatment is given as injections under the skin, known as subcutaneous injections.

Are there any costs to participate in this study?

No. If you choose to be in this study, study treatment will be provided to you at no cost. There will be no charge to you for any tests, examinations, and visits done as part of this study. You may be reimbursed for travel costs and out of pocket expenses related to this study, and may also receive compensation for your time and effort.

Still Have Questions?

Contact us anytime at help@clinicalenrollment.com.

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